Haematology

What is the mechanism of action of apixaban?

Factor Xa inhibitor

What effect may grapefruit juice have on apixaban?

Increased levels / effects

What is the mechanism of action of bivalirudin?

Direct thrombin inhibitor

What is the mechanism of action of dabigatran?

Direct thrombin inhibitor

What is the mechanism of action of fondaparinux?

Factor Xa inhibitor

What is the mechanism of action of warfarin?

Vitamin K antagonist

What is the approximate half-life of warfarin?

Mean 40 hours - range 20 to 60 hours but highly variable

What is the approximate duration of action of warfarin?

2 to 5 days

Which organ is the main site of warfarin metabolism?

Liver

Through which route is warfarin mainly excreted?

Urine