Gastroenterology

What important side-effect can amiodarone have on the liver?

Cirrhosis

What side-effect can bismuth have on teeth?

Black discolouration

What class of drug is chlordiazepoxide?

Benzodiazepine

What is the mechanism of action of cimetidine?

Histamine H2 receptor antagonist

What is the mechanism of action of cyclizine?

Histamine H1 antagonist

What is the mechanism of action of mesalazine?

5-aminosalicylic acid derivative

What is the mechanism of action of sulfasalazine?

5-aminosalicylic acid derivative

List 3 classes of drug to which metoclopramide belongs

1) Dopamine antagonist 2) Serotonin 5-HT4 receptor agonist 3) Prokinetic AMEND

What is the mechanism of action of ondansetron?

5-HT3 receptor antagonist

What is the approximate onset of action of ondansetron?

30 minutes

What is the mechanism of action of omeprazole?

Proton pump inhibitor (PPI)

What effect can a proton pump inhibitor have on platelet count?

Decreases - thrombocytopenia

In paracetamol overdose what should be the timing of serum levels?

4 hours post ingestion

What is the antidote/treatment in paracetamol overdose?

N-acetylcysteine (NAC)

Which viral hepatitis infection can ribarvirin be used for?

Hepatitis C

Is ribavirin safe in pregnancy?

No – highly teratogenic

What is the mechanism of action of terlipressin?

Vasopressin analogue

What is the route of administration for terlipressin?

Intravenous

What effect does terlipressin have on blood vessels?

Vasoconstriction